Cd98hc protein
WebDescription: The monoclonal antibody 5E5 recognizes human CD98hc protein also called CD98 heavy chain, FRP-1 (fusion regulatory protein-1 ) or 4F2. CD98 is a disulfide-linked complex composed of a heavy chain …
Cd98hc protein
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WebUsing chimeras of CD98hc and the type II membrane protein CD69, we show that the transmembrane domain of CD98hc is necessary and sufficient for integrin association in cells. Furthermore, CD98hc/β 1 integrin association is required for focal adhesion kinase-dependent phosphoinositol 3-hydroxykinase activation and cellular transformation. Amino ... WebApr 9, 2024 · Human Protein Recombinants; In Vitro Diagnostics; MaxPab® Polyclonal Antibodies; Proteoliposomes; Hard-to-Find Antibodies; All Product Showcase; Product Map; Services. Integrated Solutions & Services; Gene Synthesis & Cytogenetics. Assembly PCR; FISH Probes ; mutaFISH™ Probes; Peptide Services. Peptide Design & Synthesis; …
WebMar 22, 2024 · CD98 is a heteromeric solute carrier formed by two subunits, a heavy and a light chain [ 14 ]. The heavy chain, known as CD98hc or SLC3A2, is an ≈80 kDa type II … WebNov 24, 2024 · The cell-surface glycoprotein CD98—a subunit of the LAT1/CD98 amino acid transporter—is an attractive target for cancer immunotherapies, but its widespread expression has hampered the development...
WebJan 29, 2016 · In a recent study, Watts and colleagues identified proteins that are expressed at high levels at the BBB, including CD98 heavy chain (CD98hc), and could be exploited … WebMay 20, 2024 · The eukaryotic protein CD98hc (also known as 4F2, FRP-1 or SLC3A2) is a membrane glycoprotein and one of the heavy chains of the family of heterodimeric amino …
WebApr 8, 2024 · Since γ-secretase mediates the final cleavage that liberates Aβ, γ-secretase has been widely studied as a potential drug target for the treatment of AD. γ-Secretase is a transmembrane protein...
WebThe aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the effects of the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Recently, AHR has kyle creasyWebOct 7, 2015 · The CD98 heavy chain (CD98hc, Slc3a2) plays a crucial role in the proliferation of both CD4 + and CD8 + T cells, although it is unclear if CD98hc directly … program listing for directvWebNov 29, 2016 · System L is heteromeric, composed of a heavy glycoprotein chain (CD98hc, encoded by SLC3A2 ), and is one of two catalytic L chains, LAT1 or LAT2, encoded by SLC7A5 and SLC7A8 genes, respectively. CD98hc-independent transporters LAT3 and LAT4 were also suggested to play a role in DOPA uptake [ 10 ]. program living solutions jumbo remoteWebCD98 is a multifunctional glycoprotein that is involved in various biological processes such as amino acid transport, cell adhesion, diffusion, adhesion, and proliferation. The role of CD98 in... kyle creasy obituary sun city center flWebThe type II glycoprotein CD98 (SLC3A2) is a membrane protein with pleiotropic roles in cells, ranging from modulation of inflammatory processes, host–pathogen interactions to association with membrane transporters of the SLC7 family. The recent kyle crawshaw dentistWebDec 2, 2024 · In separate studies, they found that the overexpression of a specific region of the CD98hc protein (the high homology, or HH domain) prevents mechanical activation of TRPV4, so the team hypothesized that a gene therapy delivering that region of the protein to lung cells could be an effective treatment for vascular leakage in the lung that leads … kyle cray attorney lafayette inWebMar 18, 2024 · Among the multiple transmembrane protein clients of CRBN-AHA1-HSP90 revealed by cell surface proteomics, we identify the amino acid transporter LAT1/CD98hc as a determinant of IMiD activity in multiple myeloma (MM) and present an Anticalin-based CD98hc radiopharmaceutical for MM radio-theranostics. kyle creed