Circrna accumulation: a new hallmark of aging
WebAccumulation of circular RNAs (circRNAs) during aging occurs on a genome-wide level for multiple organisms, but its significance is unknown. Generating circRNA loss-of … WebNov 20, 2024 · Knupp D, Miura P (2024) CircRNA accumulation: a new hallmark of aging? Mech Ageing Dev 173:71–79. CrossRef Google Scholar Kojima H, Kunimoto H, Inoue T et al (2012) The STAT3-IGFBP5 axis is critical for IL-6/gp130-induced premature senescence in human fibroblasts. Cell Cycle 11:730–739
Circrna accumulation: a new hallmark of aging
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WebThese closed loop, single-stranded RNA molecules are highly stable, enriched in the brain, and functionally active in both healthy and disease conditions. Current evidence implicating this ancient class of RNA as a contributor toward higher-order functions such as cognition and memory is discussed. Keywords circRNA, WebMay 10, 2024 · Circular RNAs (circRNAs) are a newly appreciated class of RNAs found across phyla that are generated most commonly from back-splicing of protein-coding …
WebDec 31, 2024 · Knupp D, Miura P. Circrna accumulation: A new hallmark of aging?Mech Ageing Dev. 2024; 173:71–9. Article CAS PubMed PubMed Central Google Scholar Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, et al. Circular rnas are a large class of animal rnas with … WebJan 3, 2024 · Global circRNA accumulation during aging. a Principal component analysis of circRNA Transcripts Per Million reads (TPM) shows clear clustering of young (L4, D …
WebDec 31, 2024 · Circular RNAs (circRNA) are a subclass of non-coding RNAs with a covalently closed loop structure that are formed via non-canonical splicing 1. CircRNAs are specifically enriched in the brain among different species and further accumulate in the brain as a function of physiological aging 2. WebMar 1, 2024 · CircRNA could play a role in aging, such as neural aging, muscle aging, reproductive aging, skin aging, immunosenescence, visual aging and age-related …
WebDownload scientific diagram Global circRNA accumulation during aging. a Principal component analysis of circRNA Transcripts Per Million reads (TPM) shows clear …
WebOct 27, 2024 · RNAs (circRNAs) are a recently re-discovered class of endo- genous RNAs that are generated from exons, introns, or both via a diverse number of cellular mechanisms. Rapid progress in... irct trialWebJul 2, 2024 · Whereas global circRNA expression increased with age in brain tissue of wild-type Drosophila melanogaster, the increase was significantly lower in the brain of long … irct taxisWebMay 16, 2024 · Europe PMC is an archive of life sciences journal literature. order custom gift boxesWebAug 29, 2024 · In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, … order custom glassWebJul 16, 2024 · Here, we use transcriptome profiling during aging and find that accumulation of circRNAs is slowed down in long-lived insulin mutant flies. Next, we characterize the in vivo function of a circRNA generated by the sulfateless gene (circSfl), which is consistently upregulated, particularly in the brain and muscle, of diverse long-lived insulin ... order custom gift cardsWebCircRNA could play a role in aging, such as neural aging, muscle aging, reproductive aging, skin aging, immunosenescence, visual aging and age-related diseases like … irct talhoWebJul 1, 2024 · The circRNA age-accumulation trends found in various animals suggest that they could serve as biomarkers of age. When profiling multiple aging time-points from … irct thailand