WebTo compare the effectiveness of various bioactive agents reversibly acting within a cell on a target intracellular macromolecule, it is necessary to assess effective cytoplasmic concentrations of the delivered bioactive agents. In this work, based on a simple equilibrium model and the cellular thermal shift assay (CETSA), an approach is proposed to assess …
P-bodies - Wikipedia
WebProcessing bodies (P-bodies) are cytoplasmic domains that have been implicated in critical steps of the regulation of gene expression, including mRNA decay and post-transcriptional gene silencing. Previously, we reported that PCBP2 (Poly- (rC) Binding Protein 2), a facilitator of IRES-mediated translation, is a novel P-body component. WebJul 1, 2005 · Cytoplasmic processing bodies, also known as P-bodies, concentrate enzymes that are involved in mRNA turnover and sequester mRNAs away from the translational machinery. Strong evidence now... how mount tv on wall
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WebFeb 23, 2024 · The formation and disassembly of processing bodies (p-bodies), a sub-class of RNA granules, is a mechanism to store translationally halted mRNAs and release them in response to specific conditions that has recently gained attention in different model organisms and contexts ( Decker and Parker, 2012; Wang et al., 2024; Jang et al., 2024 ). WebApr 12, 2024 · Cytoplasmic TDRD1 interacts with methylated Sm proteins in a PRMT5-dependent manner, and nuclear TDRD1 interacts with Coilin, the scaffold protein of Cajal bodies. WebSep 24, 2011 · Processing bodies (PBs) and stress granules (SGs) are two highly conserved cytoplasmic ribonucleoprotein foci that contain translationally repressed mRNAs together with proteins from the mRNA metabolism. Interestingly, they also share some common features with other granules, including the prokaryotic inclusion bodies. … how motor couplings work