Tecogalan
WebAug 31, 2001 · A Phase I Trial of Tecogalan Sodium (DS-4152) Administered as an Infusion Every 21 Days. The safety and scientific validity of this study is the responsibility of the … WebAspects of the disclosure are directed to a technique for sequential electroporation that provides for a delivery of multiple electrical pulses separated in time to cells, cell particles, lipid vesicles, liposomes, or to increase efficiency of entry of one or more agents of interest into cells, cell particles, lipid vesicles, liposomes, tissues, or derivatives thereof, and to …
Tecogalan
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Web用于防止癌细胞转移的化合物、组合物和方法专利检索，用于防止癌细胞转移的化合物、组合物和方法属于肝细胞生物学专利检索，找专利汇即可免费查询专利，肝细胞生物学专利汇是一家知识产权数据服务商，提供专利分析，专利查询，专利检索等数据服务功能。 WebThe exact mechanisms of the angiostatic effect by tecogalan sodium (TS) remain unclear. We examined the effects of TS on in vitro angiogenic activity, proteolytic activity and …
Web本申请要求2024年10月1日提交的美国临时申请序列号62/739,809和2024年11月30日提交的美国临时申请序列号62/773,980的权益，所有所 ... WebNov 3, 1999 · Tecogalan sodium [DS 4152, SP PG LM] is a polysaccharide-peptidoglycan complex isolated from an Arthrobacter species with antiangiogenic activity. Daiichi
WebTo evaluate the safety of different doses and dosing regimens of tecogalan sodium (DS-4152) and to establish the MTD at each of the different dosing schedules. Study summary: Patients receive intravenous DS-4152 by infusion twice weekly for 21 days, followed by 2 weeks of rest; courses may repeat. Patients undergo weekly follow-up. WebJan 1, 2001 · Tecogalan inhibited FGF-dependent SW-13 cells in vitro very similarly to PPS. Growth factor-independent MDA-MB 231 cells were used in animal studies to assess the …
WebJan 10, 2024 · A sulfated polysaccharide isolated from various Arthrobacter bacterial species. Possessing potential antiangiogenic and antineoplastic properties, tecogalan binds to basic fibroblast growth factor (bFGF), thereby preventing bFGF from binding to its receptors. Disruption of this receptor binding results in the inhibition of bFGF-stimulated …
WebOct 17, 2000 · The exact mechanisms of the angiostatic effect by tecogalan sodium (TS) remain unclear. We examined the effects of TS on in vitro angiogenic activity, proteolytic activity and proliferation of retinal vascular endothelial cells (RECs). TS markedly inhibited the in vitro angiogenic activity of RECs although the growth inhibition of RECs was small. … stayed on top of synonymWebThe exact mechanisms of the angiostatic effect by tecogalan sodium (TS) remain unclear. We examined the effects of TS on in vitro angiogenic activity, proteolytic activity and proliferation of retinal vascular endothelial cells (RECs). TS markedly inhibited the in vitro angiogenic activity of RECs although the growth inhibition of RECs was small. stayed openWebJan 1, 2001 · Request PDF The bacterial polysaccharide tecogalan blocks growth of breast cancer cells in vivo The growth of supportive tissue during the progression of solid tumors is an absolute ... stayed put crosswordWebJan 10, 2024 · A sulfated polysaccharide isolated from various Arthrobacter bacterial species. Possessing potential antiangiogenic and antineoplastic properties, tecogalan … stayed pursuant to pc 654WebBFGF, VEGF, and a combination of bFGF and V EGF stimulated proliferation, migration, and tube formation by CECs in vitro, and these stimulatory effects were inhibited by tecogalan sodium. PURPOSE To examine the possible inhibitory effect of tecogalan sodium, derived from bacteria, on three important components of in vitro angiogenesis … stayed out of sightWebTecogalan sodium, a sulfated polysaccharide peptidoglycan complex isolated from an Arthrobacter species, has been reported to inhibit angiogenesis induced by basic fibroblast growth factor (bFGF) as well as tumor angiogenesis related to Kaposi's sarcoma. Corneal neovascularization induced by bFGF was inhibited by tecogalan sodium in a dose ... stayed putWebTecogalan sodium (tecogalan), a bacteria-derived sulfated polysaccharide, has been reported to prevent basic fibroblast growth factor (bFGF) binding to endothelial cells. We examined whether the interference with endothelial cell-extracellular matrx interaction is involved in the anti-angiogenic activity of tecogalan. Method. stayed put clue