To prevent cisplatin nephropathy
WebMar 31, 2024 · The goal of this activity is to provide medical news to primary care clinicians and other healthcare professionals in order to enhance patient care. Upon completion of this activity, participants will be able to: Describe the mechanisms of nephrotoxic drugs. Review general preventive measure to avoid nephrotoxicity. Disclosures WebFeb 1, 2024 · Cisplatin injection is used to treat advanced cancer of the bladder, ovaries, or testicles. Cisplatin is an antineoplastic agent (cancer medicine). It interferes with the growth of cancer cells, which are eventually destroyed by the body. This medicine is to be given only by or under the direct supervision of a doctor.
To prevent cisplatin nephropathy
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WebApr 15, 2012 · The protective effects of BCP against biochemical and histological markers of nephropathy were absent in CB(2) knockout mice. Thus, BCP may be an excellent therapeutic agent to prevent cisplatin-induced nephrotoxicity through a CB(2) receptor-dependent pathway. Given the excellent safety profile of BCP in humans it has … WebNov 1, 2024 · Even after a single-dose injection of cisplatin (50–100 mg/m 2), approximately one-third of the patients develop acute kidney injury (AKI) characterized by a rapid decline in renal function. Patients with AKI have a 50% mortality rate, and surviving AKI patients are likely to develop chronic kidney disease in months to years [2].
WebJul 1, 2013 · Recent studies have identified a dual role for MΦ in several murine models of kidney disease. In this review, we discuss the pathogenic and protective roles of the various MΦ subsets in experimental and human kidney diseases and summarize current progress toward the therapeutic use of MΦ in kidney diseases. ... Cisplatin is widely used to ...
WebIntroduction: Cisplatin, a platinum-based antineoplastic agent, is the cornerstone for the … WebBackground A strategy for preventing cisplatin nephrotoxicity due to enhanced oxidative stress and inflammatory response is highly desirable. Thioredoxin-1 (Trx), an endogenous redox-active protein,
WebCisplatin-induced acute kidney injury is a serious problem in cancer patients during treatment of solid tumors. Currently, there are no therapies …
WebOct 19, 2024 · The best way to prevent or delay diabetic nephropathy is by maintaining a … traffic cams outer banksWeb1 day ago · Jasmine Shen, who was working toward her A-levels when kidney disease struck out of the blue. New anti-PAR-1 treatments could help to transform Jasmine’s life both on stage and at home. thesaurus generallyWebOct 26, 2010 · Cisplatin was first shown to inhibit cell division in 1965 . By 1969, cisplatin … thesaurus geduldWebApr 14, 2024 · Africa, particularly sub-Sharan Africa (SSA), faces major challenges in respect to chronic kidney disease (CKD). There is a rising prevalence due to the combined effects of hypertension, diabetes, and human immunodeficiency virus (HIV) (and the interaction between them) and the effect of apolipoprotein L1 (APOL1) variants on the susceptibility … thesaurus gazingWebNov 11, 2024 · Mitophagy reportedly can prevent diabetic nephropathy, cisplatin-induced AKI and other related nephropathy. In this study, we evaluated the correlation between mitophagy and the protective effect of the Nrf2 activator farrerol on cisplatin-induced CKD by using C57BL/6 wild-type and Nrf2 knockout mice. thesaurus generatingWebDec 13, 2024 · DS-5272 co-treatment reduced both cisplatin-induced cell death and NFκB transcriptional activity. Collectively, these findings suggest that DS-5272 can ameliorate cisplatin nephrotoxicity via NFκB signal inhibition. Abbreviations LDH thesaurus generatedWebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose … thesaurus general